| PackageDescription | Immunoglobulin Clonal Lineage and Diversity Analysis
Alakazam is part of the Immcantation analysis framework for Adaptive
Immune Receptor Repertoire sequencing (AIRR-seq) and provides a set of
tools to investigate lymphocyte receptor clonal lineages, diversity,
gene usage, and other repertoire level properties, with a focus on
high-throughput immunoglobulin (Ig) sequencing.
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Alakazam serves five main purposes:
* Providing core functionality for other R packages in the Immcantation
framework. This includes common tasks such as file I/O, basic DNA
sequence manipulation, and interacting with V(D)J segment and gene
annotations.
* Providing an R interface for interacting with the output of the
pRESTO and Change-O tool suites.
* Performing lineage reconstruction on clonal populations of Ig
sequences and analyzing the topology of the resultant lineage trees.
* Performing clonal abundance and diversity analysis on lymphocyte
repertoires.
* Performing physicochemical property analyses of lymphocyte receptor
sequences. |